Burkholderia cenocepacia J2315, BCAL0409 (paaF)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0409
NCBI Locus Tag	QU43_RS38580
Name	paaF
Replicon	chromosome 1
Genomic location	443179 - 443955 (+ strand)

Cross-References

RefSeq	WP_006491102.1
GI	206558815
Entrez	6933925
GI	206558815
INSDC	CAR50720.1
NCBI Locus Tag	QU43_RS38580
NCBI Old Locus Tag	BCAL0409
RefSeq	WP_006491102.1,GeneID
UniParc	UPI00017B8ED7
UniProtKB Acc	B4E7C0
UniProtKB ID	B4E7C0_BURCJ
UniRef100	UniRef100_A0A095DTU6
UniRef50	UniRef50_A0R2Y5
UniRef90	UniRef90_A0A0B6RS26

Product

Feature Type	CDS
Coding Frame	1
Product Name	enoyl-CoA hydratase Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7)	-3.37
Kyte-Doolittle Hydrophobicity Value	0.074
Molecular Weight (kDa)	27995.1
Isoelectric Point (pI)	5.45

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 508 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000434 (657 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0409 Search term: paaF Search term: enoyl-CoA hydratase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000357535 enoyl-CoA hydratase, short chain 1 [Source:HGNC Symbol;Acc:HGNC:3151] E-value: 4.6e-74 Percent Identity: 56.4

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model. Law RJ, Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST J Bacteriol 2008 Nov;190(21):7209-18 PubMed ID: 18776009