Burkholderia cenocepacia J2315, BCAL0212 (paaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0212
NCBI Locus TagQU43_RS37550
Name
paaE
Replicon chromosome 1
Genomic location 240459 - 241547 (- strand)

Cross-References

RefSeq WP_006482925.1
GI 206558619
Entrez 6930836
GI 206558619
INSDC CAR50523.1
NCBI Locus Tag QU43_RS37550
NCBI Old Locus Tag BCAL0212
RefSeq WP_006482925.1,GeneID
UniParc UPI00017B8FCB
UniProtKB Acc B4E598
UniProtKB ID B4E598_BURCJ
UniRef100 UniRef100_A0A095EW86
UniRef50 UniRef50_Q0K5Y8
UniRef90 UniRef90_Q63PZ0

Product

Feature Type CDS
Coding Frame 1
Product Name
putative phenylacetic acid degradation NADH oxidoreductase PaaE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -12.09
Kyte-Doolittle Hydrophobicity Value -0.150
Molecular Weight (kDa) 40036.3
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Phenylacetic acid catabolism
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes paaE mutation diminishes virulence of B. cenocepacia K56-2 in the C. elegans model of infection
Reference 18776009

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 421 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000236 (651 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0212
Search term: paaE

Human Homologs

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ, Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST
J Bacteriol 2008 Nov;190(21):7209-18
PubMed ID: 18776009