Burkholderia cenocepacia J2315, BCAL0207 (hppD)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0207
NCBI Locus Tag	QU43_RS37525
Name	hppD
Replicon	chromosome 1
Genomic location	236106 - 237203 (- strand)

Cross-References

RefSeq	WP_006482885.1
GI	206558614
Entrez	6930832
GI	206558614
INSDC	CAR50518.1
NCBI Locus Tag	QU43_RS37525
NCBI Old Locus Tag	BCAL0207
RefSeq	WP_006482885.1,GeneID
UniParc	UPI00017B8FC7
UniProtKB Acc	B4E593
UniProtKB ID	B4E593_BURCJ
UniRef100	UniRef100_B4E593
UniRef50	UniRef50_Q5ZT84
UniRef90	UniRef90_Q2STZ8

Product

Feature Type	CDS
Coding Frame	1
Product Name	4-hydroxyphenylpyruvic acid dioxygenase Product Name Confidence: Class 1
Synonyms	4-hydroxyphenylpyruvic acid dioxygenase HppD
Evidence for Translation
Charge (pH 7)	-7.40
Kyte-Doolittle Hydrophobicity Value	-0.390
Molecular Weight (kDa)	41127.1
Isoelectric Point (pI)	5.80

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	BGD
Category	Response to superoxide
Evidence	ECO:0000250 sequence similarity evidence used in manual assertion
Host Organism	Mus musculus
Notes	hppD mutation has bacterial intracellular survival in RAW 264.7 macrophages
Reference	17933889

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 221 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000231 (655 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0207 Search term: hppD Search term: 4-hydroxyphenylpyruvic acid dioxygenase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000335060 4-hydroxyphenylpyruvate dioxygenase like [Source:HGNC Symbol;Acc:HGNC:28242] E-value: 9.9e-14 Percent Identity: 32.0

References

Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate. Keith KE, Killip L, He P, Moran GR, Valvano MA J Bacteriol 2007 Dec;189(24):9057-65 PubMed ID: 17933889