Burkholderia cenocepacia J2315, BCAL0144 (fliA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0144
NCBI Locus TagQU43_RS37225
Name
fliA
Synonym: sigK
Replicon chromosome 1
Genomic location 168141 - 168872 (+ strand)

Cross-References

RefSeq YP_002229309.1
GI 206558549
Entrez 6930774
GI 206558549
INSDC CAR50452.1
NCBI Locus Tag QU43_RS37225
NCBI Old Locus Tag BCAL0144
RefSeq YP_002229309.1
UniParc UPI00017B8EFF
UniProtKB Acc B4EE69
UniProtKB ID B4EE69_BURCJ
UniRef100 UniRef100_B4EE69
UniRef50 UniRef50_B2JJ28
UniRef90 UniRef90_B1YR52

Product

Feature Type CDS
Coding Frame 1
Product Name
flagellar biosynthesis sigma factor
Product Name Confidence: Class 1
Synonyms sigma factor 70 SigK
Evidence for Translation
Charge (pH 7) -11.10
Kyte-Doolittle Hydrophobicity Value -0.472
Molecular Weight (kDa) 27745.0
Isoelectric Point (pI) 4.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0430
Category Flagella
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 586 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000177 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0144
Search term: fliA

Human Homologs

References

Architecture of Burkholderia cepacia complex sigma70 gene family: evidence of alternative primary and clade-specific factors, and genomic instability.
Menard A, de Los Santos PE, Graindorge A, Cournoyer B
BMC Genomics 2007 Sep 4;8:308
PubMed ID: 17784948