Burkholderia multivorans ATCC 17616, Bmul_6008 (ampC1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_6008
NCBI Locus TagBMUL_RS30175
Name
ampC1
Synonym: ampC
Replicon chromosome 3
Genomic location 744654 - 745823 (- strand)
CommentAmpC1 from B. multivorans ATCC 17616 possesses a narrow spectrum, and the contribution of AmpC1 to _-lactam resistance appears to be negligible, yet expression of AmpC1 is regulated by _-lactam inducers including imipenem (PMID:30012762).

Cross-References

RefSeq WP_012218336.1
GI 161523029
Entrez 5770400
GI 161523029
NCBI Locus Tag BMUL_RS30175
NCBI Old Locus Tag Bmul_6008
RefSeq WP_012218336.1
UniProtKB Acc A9ASZ4
UniProtKB ID A9ASZ4_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
class C beta-lactamase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 9.19
Kyte-Doolittle Hydrophobicity Value 0.015
Molecular Weight (kDa) 41875.9
Isoelectric Point (pI) 9.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Extracellular Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 330 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG005235 (327 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_6008
Search term: ampC1

References

Characterization of the AmpC beta-Lactamase from Burkholderia multivorans.
Becka SA, Zeiser ET, Barnes MD, Taracila MA, Nguyen K, Singh I, Sutton GG, LiPuma JJ, Fouts DE, Papp-Wallace KM
Antimicrob Agents Chemother 2018 Oct;62(10)
PubMed ID: 30012762