Burkholderia cenocepacia MC0-3, Bcenmc03_2645 (htrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia MC0-3
GCF_000019505.1|latest
Locus Tag
Bcenmc03_2645
NCBI Locus TagBCENMC03_RS13405
Name
htrA
Replicon chromosome 1
Genomic location 2946570 - 2948051 (- strand)

Cross-References

RefSeq WP_006477953.1
GI 170733980
Entrez 6124308
GI 170733980
INSDC ACA91805.1
NCBI Locus Tag BCENMC03_RS13405
NCBI Old Locus Tag Bcenmc03_2645
RefSeq WP_006477953.1
UniParc UPI000052E2F3
UniProtKB Acc B1JXY1
UniProtKB ID B1JXY1_BURCC
UniRef100 UniRef100_B1JXY1
UniRef50 UniRef50_Q1LH84
UniRef90 UniRef90_B1YVV2

Product

Feature Type CDS
Coding Frame 1
Product Name
protease Do
Product Name Confidence: Class 2
Synonyms HtrA protease
Evidence for Translation
Charge (pH 7) 2.20
Kyte-Doolittle Hydrophobicity Value -0.053
Molecular Weight (kDa) 50957.4
Isoelectric Point (pI) 8.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 615 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002475 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bcenmc03_2645
Search term: htrA
Search term: protease Do

Human Homologs

Ensembl 97, assembly GRCh38.p12
HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406]
E-value: 3.9e-37
Percent Identity: 37.5

References

Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.
Flannagan RS, Aubert D, Kooi C, Sokol PA, Valvano MA
Infect Immun 2007 Apr;75(4):1679-89
PubMed ID: 17220310