Strain |
Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest |
Locus Tag |
BTH_II0256
|
NCBI Locus Tag | BTH_RS01330 |
Name |
ppkA-6
|
Replicon | chromosome II |
Genomic location | 313510 - 316143 (+ strand) |
Transposon Mutants | 2 transposon mutants in E264 ATCC 700388 |
Comment | This gene is part of cluster known as the type VI secretion system gene cluster tss-6 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170). |
RefSeq | YP_438458.1 |
GI | 83716861 |
Entrez | 3845191 |
GI | 83716861 |
INSDC | AIP28624.1 |
NCBI Locus Tag | BTH_RS01330 |
NCBI Old Locus Tag | BTH_II0256 |
RefSeq | WP_009895014.1 |
UniParc | UPI0000667580 |
UniProtKB Acc | Q2T8P1 |
UniProtKB ID | Q2T8P1_BURTA |
UniRef100 | UniRef100_Q2T8P1 |
UniRef50 | UniRef50_A1UYY9 |
UniRef90 | UniRef90_Q2T8P1 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
type VI secretion system-associated protein TagE-6
|
Synonyms |
serine/threonine protein kinase |
Evidence for Translation | |
Charge (pH 7) | -3.17 |
Kyte-Doolittle Hydrophobicity Value | -0.418 |
Molecular Weight (kDa) | 90706.8 |
Isoelectric Point (pI) | 6.69 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 400 genera
|
Burkholderia Ortholog Group |
BG016589 (492 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BTH_II0256
Search term: ppkA-6
Search term: type VI secretion system-associated protein TagE-6
|
Ensembl
97, assembly
GRCh38.p12
|
p21 (RAC1) activated kinase 2 [Source:HGNC Symbol;Acc:HGNC:8591]
E-value:
1.4e-13
Percent Identity:
26.3
|
Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD
PLoS Pathog 2010 Aug 26;6(8):e1001068
PubMed ID: 20865170
|
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
|
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
|
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434
|