Burkholderia pseudomallei K96243, BPSS1514 (bopB)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
Synonym: folE
Replicon chromosome 2
Genomic location 2067071 - 2067703 (+ strand)


RefSeq YP_111521.1
GI 53722536
Entrez 3095368
GI 53722536
INSDC CAH38987.1
NCBI Locus Tag BPSS1514
RefSeq YP_111521.1,GeneID
UniParc UPI000043BD0D
UniProtKB Acc Q63K51
UniRef100 UniRef100_A0A095S2W1
UniRef50 UniRef50_Q8XZK8
UniRef90 UniRef90_A3MF45


Feature Type CDS
Coding Frame 1
Product Name
putative type III secretion system effector BopB
Product Name Confidence: Class 2
Synonyms GTP cyclohydrolase I
Evidence for Translation
Charge (pH 7) -0.30
Kyte-Doolittle Hydrophobicity Value -0.207
Molecular Weight (kDa) 23628.8
Isoelectric Point (pI) 6.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 469 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019343 (296 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1514
Search term: bopB

Human Homologs


Analysis of the prevalence, secretion and function of a cell cycle-inhibiting factor in the melioidosis pathogen Burkholderia pseudomallei.
Pumirat P, Broek CV, Juntawieng N, Muangsombut V, Kiratisin P, Pattanapanyasat K, Stevens JM, Stevens MP, Korbsrisate S
PLoS One 2014;9(5):e96298
PubMed ID: 24809950
Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis.
Stevens MP, Haque A, Atkins T, Hill J, Wood MW, Easton A, Nelson M, Underwood-Fowler C, Titball RW, Bancroft GJ, Galyov EE
Microbiology 2004 Aug;150(Pt 8):2669-2676
PubMed ID: 15289563
Characterization and analysis of the Burkholderia pseudomallei BsaN virulence regulon.
Chen Y, Schröder I, French CT, Jaroszewicz A, Yee XJ, Teh BE, Toesca IJ, Miller JF, Gan YH
BMC Microbiol 2014 Aug 1;14:206
PubMed ID: 25085508