Burkholderia pseudomallei K96243, BPSL1631 (bpaC)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
Replicon chromosome 1
Genomic location 1889771 - 1893145 (+ strand)


RefSeq YP_108245.1
GI 53719259
Entrez 3094819
GI 53719259
INSDC CAH35630.1
NCBI Locus Tag BPSL1631
RefSeq YP_108245.1,GeneID
UniParc UPI000043B09A
UniProtKB Acc Q63UH1
UniRef100 UniRef100_Q63UH1
UniRef50 UniRef50_A3NVH7
UniRef90 UniRef90_Q63UH1


Feature Type CDS
Coding Frame 1
Product Name
trimeric autotransporter adhesin, BpaC
Product Name Confidence: Class 1
Synonyms outer membrane protein
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724).
Charge (pH 7) -41.83
Kyte-Doolittle Hydrophobicity Value -0.189
Molecular Weight (kDa) 104843.6
Isoelectric Point (pI) 3.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Homo sapiens
Notes bpaC mutant is sensitive to complement-mediated killing by normal human serum via the classical and/or lectin pathway of complement system.
Reference 25830295
Source 2
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes bpaC mutation has reduced net intracellular replication in J774.2 murine macrophage-like cells
Reference 25830295

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 121 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002926 (1913 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BPSL1631
Search term: bpaC

Human Homologs


Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.
Lazar Adler NR, Stevens MP, Dean RE, Saint RJ, Pankhania D, Prior JL, Atkins TP, Kessler B, Nithichanon A, Lertmemongkolchai G, Galyov EE
PLoS One 2015;10(4):e0121271
PubMed ID: 25830295