Burkholderia cenocepacia K56-2, WQ49_RS13890 (paaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2
GCF_000981305.1|latest
Locus Tag
WQ49_RS13890
NCBI Old Locus TagWQ49_13890
Name
paaE
Replicon scf7180000000054
Genomic location 294043 - 295131 (- strand)

Cross-References

RefSeq WP_006482925.1
GI 493528908
NCBI Locus Tag WQ49_RS13890
NCBI Old Locus Tag WQ49_13890
RefSeq WP_006482925.1

Product

Feature Type CDS
Coding Frame 1
Product Name
PaaE
Product Name Confidence: Class 2
Synonyms phenylacetic acid degradation protein
Evidence for Translation
Charge (pH 7) -12.09
Kyte-Doolittle Hydrophobicity Value -0.150
Molecular Weight (kDa) 40036.3
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000236 (651 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: WQ49_RS13890
Search term: paaE
Search term: PaaE

Human Homologs

References

A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ, Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST
J Bacteriol 2008 Nov;190(21):7209-18
PubMed ID: 18776009
Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex.
Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M
J Biol Chem 2011 Mar 25;286(12):10735-43
PubMed ID: 21247899