Burkholderia cenocepacia H111, I35_RS29310 (copA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia H111
GCF_000236215.2|latest
Locus Tag
I35_RS29310
NCBI Old Locus TagI35_0281%2CI35_6577
Name
copA
Replicon chromosome 2
Genomic location 2940370 - 2942943 (+ strand)
CommentRequired for growth in the presence of 20__M CuSO4 (PMID:32090500)

Cross-References

RefSeq WP_046338150.1
GI 810410218
NCBI Locus Tag I35_RS29310
NCBI Old Locus Tag I35_0281%2CI35_6577
RefSeq WP_046338150.1

Product

Feature Type CDS
Coding Frame 1
Product Name
Copper-exporting P-type ATPase, CopA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 4.46
Kyte-Doolittle Hydrophobicity Value 0.344
Molecular Weight (kDa) 87178.2
Isoelectric Point (pI) 7.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004290 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: I35_RS29310
Search term: copA

Human Homologs

Ensembl 97, assembly GRCh38.p12
ATPase copper transporting beta [Source:HGNC Symbol;Acc:HGNC:870]
E-value: 1.6e-110
Percent Identity: 34.3

Human Homologs

Ensembl 97, assembly GRCh38.p12
ATPase copper transporting beta [Source:HGNC Symbol;Acc:HGNC:870]
E-value: 1.6e-110
Percent Identity: 34.3

References

Copper resistance genes of Burkholderia cenocepacia H111 identified by transposon sequencing.
Higgins S, Gualdi S, Pinto-Carbó M, Eberl L
Environ Microbiol Rep 2020 Apr;12(2):241-249
PubMed ID: 32090500
Measurement of cytoplasmic copper, silver, and gold with a lux biosensor shows copper and silver, but not gold, efflux by the CopA ATPase of Escherichia coli.
Stoyanov JV, Magnani D, Solioz M
FEBS Lett 2003 Jul 10;546(2-3):391-4
PubMed ID: 12832075