Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS12675 (mgtC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS12675
NCBI Old Locus TagBURCENK562V_C4003
Name
mgtC
Replicon ctg7180000002940B
Genomic location 1506054 - 1506761 (+ strand)

Cross-References

RefSeq WP_006483946.1
GI 493529931
GI 493529931
NCBI Locus Tag BURCENK562V_RS12675
NCBI Old Locus Tag BURCENK562V_C4003
RefSeq WP_006483946.1

Product

Feature Type CDS
Coding Frame 1
Product Name
MgtC
Product Name Confidence: Class 1
Synonyms methyltransferase
Evidence for Translation
Charge (pH 7) 2.59
Kyte-Doolittle Hydrophobicity Value 0.347
Molecular Weight (kDa) 24803.6
Isoelectric Point (pI) 8.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category MgtC
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes mgtC mutant is defective for survival within murine RAW 264.7 macrophages
Reference 16988222

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003717 (642 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: mgtC
Search term: MgtC

Human Homologs

References

The mgtC gene of Burkholderia cenocepacia is required for growth under magnesium limitation conditions and intracellular survival in macrophages.
Maloney KE, Valvano MA
Infect Immun 2006 Oct;74(10):5477-86
PubMed ID: 16988222