Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29110 (wbiG)

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
NCBI Old Locus TagBURCENK562V_C5753
Replicon ctg7180000002940C
Genomic location 111164 - 112129 (+ strand)
CommentBelongs to the O antigen biosynthesis gene cluster


RefSeq WP_006493016.1
GI 493539126
GI 493539126
NCBI Locus Tag BURCENK562V_RS29110
NCBI Old Locus Tag BURCENK562V_C5753
RefSeq WP_006493016.1


Feature Type CDS
Coding Frame 1
Product Name
putative epimerase/dehydratase WbiG
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) 3.33
Kyte-Doolittle Hydrophobicity Value -0.037
Molecular Weight (kDa) 34579.1
Isoelectric Point (pI) 8.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category Lipopolysaccharide O antigen
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes wbiG mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 15213146

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000740 (630 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: wbiG

Human Homologs


A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737
Insect Gut Symbiont Susceptibility to Host Antimicrobial Peptides Caused by Alteration of the Bacterial Cell Envelope.
Kim JK, Son DW, Kim CH, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
J Biol Chem 2015 Aug 21;290(34):21042-53
PubMed ID: 26116716