Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29110 (wbiG)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest |
| Locus Tag |
BURCENK562V_RS29110
|
| NCBI Old Locus Tag | BURCENK562V_C5753 |
| Name |
wbiG
|
| Replicon | ctg7180000002940C |
| Genomic location | 111164 - 112129 (+ strand) |
| Comment | Belongs to the O antigen biosynthesis gene cluster |
Cross-References
| RefSeq | WP_006493016.1 |
| GI | 493539126 |
| GI | 493539126 |
| NCBI Locus Tag | BURCENK562V_RS29110 |
| NCBI Old Locus Tag | BURCENK562V_C5753 |
| RefSeq | WP_006493016.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
putative epimerase/dehydratase WbiG
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | 3.33 |
| Kyte-Doolittle Hydrophobicity Value | -0.037 |
| Molecular Weight (kDa) | 34579.1 |
| Isoelectric Point (pI) | 8.33 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Virulence Evidence
| Source 1 | |
| Database | BGD |
| Category | Lipopolysaccharide O antigen |
| Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
| Host Organism | Rattus norvegicus |
| Notes | wbiG mutant attenuated for virulence in agar bead model of chronic lung infection |
| Reference | 15213146 |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG000740 (630 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BURCENK562V_RS29110
Search term: wbiG
Search term: putative epimerase/dehydratase WbiG
|
Human Homologs
References
|
A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737
|
|
Insect Gut Symbiont Susceptibility to Host Antimicrobial Peptides Caused by Alteration of the Bacterial Cell Envelope.
Kim JK, Son DW, Kim CH, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
J Biol Chem 2015 Aug 21;290(34):21042-53
PubMed ID: 26116716
|