Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29090 (wbxE)

Cytoplasmic Membrane
Outer Membrane

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
Locus Tag
NCBI Old Locus TagBURCENK562V_C5749
Replicon ctg7180000002940C
Genomic location 105970 - 107340 (+ strand)
CommentB cenocepacia J2315, but not K56-2, is O-antigen deficient due to a transposon insertion in this gene.
CommentBelongs to the O antigen biosynthesis gene cluster


RefSeq WP_006493017.1
GI 493539127
EC Number 2.4.-.-
GI 493539127
NCBI Locus Tag BURCENK562V_RS29090
NCBI Old Locus Tag BURCENK562V_C5749
RefSeq WP_006493017.1


Feature Type CDS
Coding Frame 1
Product Name
Product Name Confidence: Class 2
Synonyms glycosyltransferase, group 1 family protein
Evidence for Translation
Charge (pH 7) 8.05
Kyte-Doolittle Hydrophobicity Value 0.076
Molecular Weight (kDa) 50801.4
Isoelectric Point (pI) 9.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category Lipopolysaccharide O antigen
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes wbcE mutant attenuated for virulence in agar bead model of chronic lung infection
Reference 15213146

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG037146 (32 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: wbxE
Search term: WbxE

Human Homologs


A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737
Reconstitution of O-specific lipopolysaccharide expression in Burkholderia cenocepacia strain J2315, which is associated with transmissible infections in patients with cystic fibrosis.
Ortega X, Hunt TA, Loutet S, Vinion-Dubiel AD, Datta A, Choudhury B, Goldberg JB, Carlson R, Valvano MA
J Bacteriol 2005 Feb;187(4):1324-33
PubMed ID: 15687196