Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS29065 (rmlD)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest |
| Locus Tag |
BURCENK562V_RS29065
|
| NCBI Old Locus Tag | BURCENK562V_C5744 |
| Name |
rmlD
|
| Replicon | ctg7180000002940C |
| Genomic location | 100357 - 101265 (+ strand) |
Cross-References
| RefSeq | WP_006485121.1 |
| GI | 493531118 |
| EC Number | 1.1.1.133 |
| GI | 493531118 |
| NCBI Locus Tag | BURCENK562V_RS29065 |
| NCBI Old Locus Tag | BURCENK562V_C5744 |
| RefSeq | WP_006485121.1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
dTDP-4-dehydrorhamnose reductase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -4.07 |
| Kyte-Doolittle Hydrophobicity Value | -0.097 |
| Molecular Weight (kDa) | 32876.7 |
| Isoelectric Point (pI) | 5.41 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Virulence Evidence
| Source 1 | |
| Database | BGD |
| Category | Lipopolysaccharide O antigen |
| Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
| Host Organism | Rattus norvegicus |
| Notes | rmlD mutant attenuated for virulence in agar bead model of chronic lung infection |
| Reference | 15213146 |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG000733 (642 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BURCENK562V_RS29065
Search term: rmlD
Search term: dTDP-4-dehydrorhamnose reductase
|
Human Homologs
|
Ensembl
97, assembly
GRCh38.p12
|
methionine adenosyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:6905]
E-value:
2.1e-17
Percent Identity:
31.1
|
|
Ensembl
97, assembly
GRCh38.p12
|
methionine adenosyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:6905]
E-value:
2.1e-17
Percent Identity:
31.1
|
References
|
A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo.
Loutet SA, Flannagan RS, Kooi C, Sokol PA, Valvano MA
J Bacteriol 2006 Mar;188(6):2073-80
PubMed ID: 16513737
|
|
A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis.
Yoo HG, Kwon SY, Karki S, Kwon HJ
Bioorg Med Chem Lett 2011 Jul 1;21(13):3914-7
PubMed ID: 21640586
|