Burkholderia cenocepacia K56-2Valvano, BURCENK562V_RS32100 (zmpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia cenocepacia K56-2Valvano
GCF_000333155.2|latest
Locus Tag
BURCENK562V_RS32100
NCBI Old Locus TagBURCENK562V_C7127
Name
zmpA
Replicon ctg7180000002943
Genomic location 224869 - 226566 (- strand)

Cross-References

RefSeq WP_006481898.1
GI 493527868
EC Number 3.4.24.-
GI 493527868
NCBI Locus Tag BURCENK562V_RS32100
NCBI Old Locus Tag BURCENK562V_C7127
RefSeq WP_006481898.1

Product

Feature Type CDS
Coding Frame 1
Product Name
zinc metalloprotease ZmpA
Product Name Confidence: Class 1
Synonyms peptidase M4
Evidence for Translation
Charge (pH 7) 3.58
Kyte-Doolittle Hydrophobicity Value -0.282
Molecular Weight (kDa) 59904.0
Isoelectric Point (pI) 8.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Extracellular Class 3
Extracellular Class 1
Western blot evidence used in manual assertion
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Virulence Evidence

Source 1
Database BGD
Category ZmpA protease
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Rattus norvegicus
Notes zmpA mutant is attenuated for virulence in agar bead model of chronic lung infection
Reference 12904566

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003484 (514 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: zmpA

Human Homologs

References

An extracellular zinc metalloprotease gene of Burkholderia cepacia.
Corbett CR, Burtnick MN, Kooi C, Woods DE, Sokol PA
Microbiology 2003 Aug;149(Pt 8):2263-2271
PubMed ID: 12904566