Burkholderia cenocepacia J2315, BCAL0040 (hemE)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAL0040
NCBI Locus Tag	QU43_RS36690
Name	hemE
Replicon	chromosome 1
Genomic location	44321 - 45415 (+ strand)

Cross-References

RefSeq	YP_002229204.1
GI	206558444
Entrez	6933957
GI	206558444
INSDC	CAR50346.1
NCBI Locus Tag	QU43_RS36690
NCBI Old Locus Tag	BCAL0040
RefSeq	YP_002229204.1
UniParc	UPI00017B9124
UniProtKB Acc	B4EEZ3
UniProtKB ID	DCUP_BURCJ
UniRef100	UniRef100_B4EEZ3
UniRef50	UniRef50_Q5ZTY0
UniRef90	UniRef90_A4JA40

Product

Feature Type	CDS
Coding Frame	1
Product Name	uroporphyrinogen decarboxylase
Synonyms
Evidence for Translation
Charge (pH 7)	-5.62
Kyte-Doolittle Hydrophobicity Value	-0.071
Molecular Weight (kDa)	39544.5
Isoelectric Point (pI)	6.00

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
4EXQ	BIOSYNTHETIC PROTEIN	04/30/12	CRYSTAL STRUCTURE of UROPORPHYRINOGEN DECARBOXYLASE (UPD) FROM BURKHOLDERIA THAILANDENSIS E264	BURKHOLDERIA THAILANDENSIS	1.65	X-RAY DIFFRACTION	93.1

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 475 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000096 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAL0040 Search term: hemE Search term: uroporphyrinogen decarboxylase

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000246337 uroporphyrinogen decarboxylase [Source:HGNC Symbol;Acc:HGNC:12591] E-value: 5.1e-87 Percent Identity: 47.6

References