Burkholderia cenocepacia J2315, BCAS0591

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAS0591
NCBI Locus TagQU43_RS71605
Name
Replicon chromosome 3
Genomic location 645029 - 646246 (+ strand)
CommentMember of rnd-1 operon encoding Resistance-Nodulation-Cell Division (RND) efflux pump RND-1

Cross-References

RefSeq YP_002153973.1
GI 197295432
Entrez 6804417
GI 197295432
INSDC CAR57523.1
NCBI Locus Tag QU43_RS71605
NCBI Old Locus Tag BCAS0591
RefSeq YP_002153973.1
UniParc UPI00017BB04A
UniProtKB Acc B4ENY5
UniProtKB ID B4ENY5_BURCJ
UniRef100 UniRef100_B4ENY5
UniRef50 UniRef50_A0A095EK62
UniRef90 UniRef90_A0A095EK62

Product

Feature Type CDS
Coding Frame 1
Product Name
RND-1 efflux system membrane fusion protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.94
Kyte-Doolittle Hydrophobicity Value -0.115
Molecular Weight (kDa) 42662.5
Isoelectric Point (pI) 8.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 416 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG006898 (62 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAS0591

Human Homologs

References

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.
Buroni S, Pasca MR, Flannagan RS, Bazzini S, Milano A, Bertani I, Venturi V, Valvano MA, Riccardi G
BMC Microbiol 2009 Sep 17;9:200
PubMed ID: 19761586
Efflux pump-mediated drug resistance in Burkholderia.
Podnecky NL, Rhodes KA, Schweizer HP
Front Microbiol 2015;6:305
PubMed ID: 25926825