Burkholderia cenocepacia J2315, BCAL2944 (hldD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0008712 ADP-glyceromanno-heptose 6-epimerase activity
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 16513737 Reviewed by curator
Biological Process GO:0009244 lipopolysaccharide core region biosynthetic process
IGC
Inferred from Genomic Context 		ECO:0000177
genomic context evidence
Biological Process GO:0009244 lipopolysaccharide core region biosynthetic process
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 16513737 Reviewed by curator
Molecular Function GO:0008712 ADP-glyceromanno-heptose 6-epimerase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01601
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0005975 carbohydrate metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01601
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050662 coenzyme binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01370
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0003824 catalytic activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF01370
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0050661 NADP binding
ISM
Inferred from Sequence Model
Term mapped from: InterPro:MF_01601
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Pathways

Database Xref Pathway Version Evidence PMID
KEGG (InterPro) 00540 Lipopolysaccharide biosynthesis InterPro 5.36-75.0 ECO:0000259
match to InterPro signature evidence used in automatic assertion
KEGG bcj00540 Lipopolysaccharide biosynthesis 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG bcj01100 Metabolic pathways 73.0+/03-31, Mar 15 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
TIGRFAM TIGR02197 heptose_epim: ADP-glyceromanno-heptose 6-epimerase IPR011912 ADP-L-glycero-D-manno-heptose-6-epimerase 3 327 8.2E-134
Hamap MF_01601 ADP-L-glycero-D-manno-heptose-6-epimerase [hldD]. IPR011912 ADP-L-glycero-D-manno-heptose-6-epimerase 2 329 49.633
Pfam PF01370 NAD dependent epimerase/dehydratase family IPR001509 NAD-dependent epimerase/dehydratase 4 241 1.0E-42
Gene3D G3DSA:3.40.50.720 4 323 1.4E-128
Gene3D G3DSA:3.90.25.10 167 310 1.4E-128
SUPERFAMILY SSF51735 IPR036291 NAD(P)-binding domain superfamily 1 327 1.44E-57
CDD cd05248 ADP_GME_SDR_e IPR011912 ADP-L-glycero-D-manno-heptose-6-epimerase 2 326 1.4812E-165

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.