Burkholderia multivorans ATCC 17616, BMULJ_RS27615 (ampC1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000010545.1
GCF_000010545.1|latest
Locus Tag
BMULJ_RS27615
Name
ampC1
Synonym: ampC
Replicon chromosome 3
Genomic location 179035 - 180204 (+ strand)
CommentAmpC1 from B. multivorans ATCC 17616 possesses a narrow spectrum, and the contribution of AmpC1 to _-lactam resistance appears to be negligible, yet expression of AmpC1 is regulated by _-lactam inducers including imipenem (PMID:30012762).

Cross-References

RefSeq WP_012218336.1
GI 0

Product

Feature Type CDS
Coding Frame 1
Product Name
class C beta-lactamase
Product Name Confidence: Class 2
Evidence for Translation
Charge (pH 7) 9.19
Kyte-Doolittle Hydrophobicity Value 0.015
Molecular Weight (kDa) 41875.9
Isoelectric Point (pI) 9.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Pathogen Association Analysis

Results Analysis not done

Orthologs/Comparative Genomics

Burkholderia Ortholog Group
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BMULJ_RS27615
Search term: ampC1

Human Homologs

References

Characterization of the AmpC beta-Lactamase from Burkholderia multivorans.
Becka SA, Zeiser ET, Barnes MD, Taracila MA, Nguyen K, Singh I, Sutton GG, LiPuma JJ, Fouts DE, Papp-Wallace KM
Antimicrob Agents Chemother 2018 Oct;62(10)
PubMed ID: 30012762