Burkholderia multivorans ATCC 17616, Bmul_3689 (penA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia multivorans ATCC 17616 - Assembly GCF_000018505.1
GCF_000018505.1|latest
Locus Tag
Bmul_3689
NCBI Locus TagBMUL_RS18715
Name
penA
Replicon chromosome 2
Genomic location 639463 - 640371 (+ strand)
CommentB. multivorans PenA is an inhibitor-resistant carbapenemase, whereas the B. pseudomallei PenA is an extended spectrum beta-lactamase (PMID:27620956).

Cross-References

RefSeq WP_012216561.1
GI 161520238
Entrez 5769488
GI 161520238
NCBI Locus Tag BMUL_RS18715
NCBI Old Locus Tag Bmul_3689
RefSeq WP_012216561.1
UniProtKB Acc A9ANW2
UniProtKB ID A9ANW2_BURM1

Product

Feature Type CDS
Coding Frame 1
Product Name
class A beta-lactamase, PenA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 5.83
Kyte-Doolittle Hydrophobicity Value -0.023
Molecular Weight (kDa) 31725.7
Isoelectric Point (pI) 9.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3W4Q HYDROLASE 01/10/13 Crystal structure of PenA beta-lactamase from Burkholderia multivorans at pH4.2 BURKHOLDERIA MULTIVORANS 1.2 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 140 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003909 (644 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Bmul_3689
Search term: penA

Human Homologs

References

Characterization of the AmpC beta-Lactamase from Burkholderia multivorans.
Becka SA, Zeiser ET, Barnes MD, Taracila MA, Nguyen K, Singh I, Sutton GG, LiPuma JJ, Fouts DE, Papp-Wallace KM
Antimicrob Agents Chemother 2018 Oct;62(10)
PubMed ID: 30012762