Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSL1631
|
Name |
bpaC
|
Replicon | chromosome 1 |
Genomic location | 1889771 - 1893145 (+ strand) |
RefSeq | YP_108245.1 |
GI | 53719259 |
Entrez | 3094819 |
GI | 53719259 |
INSDC | CAH35630.1 |
NCBI Locus Tag | BPSL1631 |
RefSeq | YP_108245.1,GeneID |
UniParc | UPI000043B09A |
UniProtKB Acc | Q63UH1 |
UniProtKB ID | Q63UH1_BURPS |
UniRef100 | UniRef100_Q63UH1 |
UniRef50 | UniRef50_A3NVH7 |
UniRef90 | UniRef90_Q63UH1 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
trimeric autotransporter adhesin, BpaC
|
Synonyms |
outer membrane protein |
Evidence for Translation |
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724).
|
Charge (pH 7) | -41.83 |
Kyte-Doolittle Hydrophobicity Value | -0.189 |
Molecular Weight (kDa) | 104843.6 |
Isoelectric Point (pI) | 3.72 |
Individual Mappings | |
Additional evidence for subcellular localization |
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).
|
Source 1 | |
Database | BGD |
Category | Trimeric autotransporter |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Mus musculus |
Notes | bpaC mutation has reduced net intracellular replication in J774.2 murine macrophage-like cells |
Reference | 25830295 |
Source 2 | |
Database | BGD |
Category | Trimeric autotransporter |
Evidence |
ECO:0000315
mutant phenotype evidence used in manual assertion
|
Host Organism | Homo sapiens |
Notes | bpaC mutant is sensitive to complement-mediated killing by normal human serum via the classical and/or lectin pathway of complement system. |
Reference | 25830295 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 121 genera
|
Burkholderia Ortholog Group |
BG002926 (1913 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSL1631
Search term: bpaC
Search term: trimeric autotransporter adhesin, BpaC
|
Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.
Lazar Adler NR, Stevens MP, Dean RE, Saint RJ, Pankhania D, Prior JL, Atkins TP, Kessler B, Nithichanon A, Lertmemongkolchai G, Galyov EE
PLoS One 2015;10(4):e0121271
PubMed ID: 25830295
|