Burkholderia glumae BGR1, bglu_2g06390 (toxR)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia glumae BGR1
GCF_000022645.2|latest |
| Locus Tag |
bglu_2g06390
|
| NCBI Locus Tag | BGLU_RS21050 |
| Name |
toxR
|
| Replicon | chromosome 2 |
| Genomic location | 767661 - 768566 (+ strand) |
Cross-References
| RefSeq | WP_012733470.1 |
| GI | |
| Entrez | 7904513 |
| NCBI Locus Tag | BGLU_RS21050 |
| NCBI Old Locus Tag | bglu_2g06390 |
| RefSeq | WP_012733470.1,GeneID |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
LysR type regulatory protein ToxR
|
| Synonyms |
LysR family transcriptional regulator |
| Evidence for Translation | |
| Charge (pH 7) | -0.89 |
| Kyte-Doolittle Hydrophobicity Value | -0.107 |
| Molecular Weight (kDa) | 33919.9 |
| Isoelectric Point (pI) | 6.80 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 266 genera
|
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG004810 (643 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: bglu_2g06390
Search term: toxR
Search term: LysR type regulatory protein ToxR
|
Human Homologs
References
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Biochemical evidence for ToxR and ToxJ binding to the tox operons of Burkholderia glumae and mutational analysis of ToxR.
Kim J, Oh J, Choi O, Kang Y, Kim H, Goo E, Ma J, Nagamatsu T, Moon JS, Hwang I
J Bacteriol 2009 Aug;191(15):4870-8
PubMed ID: 19465657
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Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
Mol Microbiol 2004 Nov;54(4):921-34
PubMed ID: 15522077
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Burkholderia glumae ToxA Is a Dual-Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis.
Fenwick MK, Philmus B, Begley TP, Ealick SE
Biochemistry 2016 May 17;55(19):2748-59
PubMed ID: 27070241
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Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B
Biochemistry 2017 Aug 1;56(30):3934-3944
PubMed ID: 28665591
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