Burkholderia cenocepacia J2315, BCAM1779

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAM1779
NCBI Locus TagQU43_RS63305
Name
Replicon chromosome 2
Genomic location 1994889 - 1995788 (- strand)

Cross-References

RefSeq WP_012493385.1
GI 206563629
Entrez 6929414
GI 206563629
INSDC CAR55638.1
NCBI Locus Tag QU43_RS63305
NCBI Old Locus Tag BCAM1779
RefSeq WP_012493385.1,GeneID
UniParc UPI00017B9F42
UniProtKB Acc B4ELT9
UniProtKB ID B4ELT9_BURCJ
UniRef100 UniRef100_B4ELT9
UniRef50 UniRef50_A9ANW2
UniRef90 UniRef90_A0A095FRL5

Product

Feature Type CDS
Coding Frame 1
Product Name
putative beta-lactamase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 1.35
Kyte-Doolittle Hydrophobicity Value 0.090
Molecular Weight (kDa) 30850.8
Isoelectric Point (pI) 7.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5IHV HYDROLASE 02/29/16 Crystal structure of a beta-lactamase from Burkholderia ambifaria BURKHOLDERIA AMBIFARIA 1.1 X-RAY DIFFRACTION 90.3

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 128 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003640 (299 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM1779

Human Homologs

References

Burkholderia pseudomallei class a beta-lactamase mutations that confer selective resistance against ceftazidime or clavulanic acid inhibition.
Tribuddharat C, Moore RA, Baker P, Woods DE
Antimicrob Agents Chemother 2003 Jul;47(7):2082-7
PubMed ID: 12821450
Erratum in: J Bacteriol. 2009 Apr;191(8):2907.
The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.
J Bacteriol. 2009 Jan;191(1):261-77.
PubMed ID: 18931103