Burkholderia cenocepacia J2315, BCAM0865

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM0865
NCBI Locus Tag	QU43_RS58705
Name
Replicon	chromosome 2
Genomic location	955451 - 956686 (- strand)
Comment	Removed gene name bceL because it was incorrectly assigned in a previous study. Analysis of other Burkholderia genomes including B. phytofirmans and B. xenovorans indicated that the protein was absent from the bce cluster.

Cross-References

RefSeq	WP_012493180.1
GI	206562721
Entrez	6930380
GI	206562721
INSDC	CAR54723.1
NCBI Locus Tag	QU43_RS58705
NCBI Old Locus Tag	BCAM0865
RefSeq	WP_012493180.1,GeneID
UniParc	UPI00017B9A2E
UniProtKB Acc	B4EMY4
UniProtKB ID	B4EMY4_BURCJ
UniRef100	UniRef100_B4EMY4
UniRef50	UniRef50_B4EMY4
UniRef90	UniRef90_B4EMY4

Product

Feature Type	CDS
Coding Frame	1
Product Name	major facilitator superfamily protein
Synonyms
Evidence for Translation
Charge (pH 7)	15.15
Kyte-Doolittle Hydrophobicity Value	0.958
Molecular Weight (kDa)	41386.6
Isoelectric Point (pI)	10.19

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 263 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004857 (604 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM0865 Search term: major facilitator superfamily protein

Human Homologs

References

Identification and physical organization of the gene cluster involved in the biosynthesis of Burkholderia cepacia complex exopolysaccharide. Moreira LM, Videira PA, Sousa SA, Leitão JH, Cunha MV, Sá-Correia I Biochem Biophys Res Commun 2003 Dec 12;312(2):323-33 PubMed ID: 14637140

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions. Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM Appl Environ Microbiol 2010 Jan;76(2):441-50 PubMed ID: 19948863