Burkholderia cenocepacia J2315, BCAM0227

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAM0227
NCBI Locus TagQU43_RS55550
Name
Replicon chromosome 2
Genomic location 281630 - 284665 (- strand)

Cross-References

RefSeq YP_002232858.1
GI 206562095
Entrez 6928022
GI 206562095
NCBI Locus Tag QU43_RS55550
NCBI Old Locus Tag BCAM0227
RefSeq YP_002232858.1
UniProtKB Acc B4EHQ8
UniProtKB ID B4EHQ8_BURCJ

Product

Feature Type CDS
Coding Frame 1
Product Name
hybrid two-component system kinase-response regulator protein
Synonyms
Evidence for Translation
Charge (pH 7) -17.53
Kyte-Doolittle Hydrophobicity Value -0.034
Molecular Weight (kDa) 108428.6
Isoelectric Point (pI) 5.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 623 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001514 (1708 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAM0227

References

A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence.
Mil-Homens D, Fialho AM.
PLoS One. 2012;7(7):e41747.
PubMed ID: 22848588
A sensor kinase recognizing the cell-cell signal BDSF (cis-2-dodecenoic acid) regulates virulence in Burkholderia cenocepacia.
McCarthy Y, Yang L, Twomey KB, Sass A, Tolker-Nielsen T, Mahenthiralingam E, Dow JM, Ryan RP.
Mol Microbiol. 2010 Sep;77(5):1220-36.
PubMed ID: 20624216