Burkholderia cenocepacia J2315, BCAM0049 (fixK)

Gene Feature Overview

Strain	Burkholderia cenocepacia J2315 GCF_000009485.1|latest
Locus Tag	BCAM0049
NCBI Locus Tag	QU43_RS54645
Name	fixK
Replicon	chromosome 2
Genomic location	55330 - 56076 (- strand)

Cross-References

RefSeq	WP_006482294.1
GI	206561919
Entrez	6927861
GI	206561919
INSDC	CAR53904.1
NCBI Locus Tag	QU43_RS54645
NCBI Old Locus Tag	BCAM0049
RefSeq	WP_006482294.1,GeneID
UniParc	UPI00017B9ADF
UniProtKB Acc	B4EG35
UniProtKB ID	B4EG35_BURCJ
UniRef100	UniRef100_B4EG35
UniRef50	UniRef50_R4WMM8
UniRef90	UniRef90_Q2T9B2

Product

Feature Type	CDS
Coding Frame	1
Product Name	FixK Product Name Confidence: Class 2
Synonyms	CRP family regulatory protein
Evidence for Translation
Charge (pH 7)	2.95
Kyte-Doolittle Hydrophobicity Value	-0.170
Molecular Weight (kDa)	27198.9
Isoelectric Point (pI)	7.83

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 458 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004455 (651 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BCAM0049 Search term: fixK Search term: FixK

Human Homologs

References

An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity. Schaefers MM, Liao TL, Boisvert NM, Roux D, Yoder-Himes D, Priebe GP PLoS Pathog 2017 Jan;13(1):e1006116 PubMed ID: 28046077