Burkholderia cenocepacia J2315, BCAL2643 (sodC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL2643
NCBI Locus TagQU43_RS49830
Name
sodC
Replicon chromosome 1
Genomic location 2909310 - 2909846 (- strand)

Cross-References

RefSeq WP_006493653.1
GI 206560982
Entrez 6933494
GI 206560982
INSDC CAR52945.1
NCBI Locus Tag QU43_RS49830
NCBI Old Locus Tag BCAL2643
RefSeq WP_006493653.1,GeneID
UniParc UPI00017B9722
UniProtKB Acc B4E8D7
UniProtKB ID B4E8D7_BURCJ
UniRef100 UniRef100_B4E8D7
UniRef50 UniRef50_A1V5V6
UniRef90 UniRef90_B4E8D7

Product

Feature Type CDS
Coding Frame 1
Product Name
superoxide dismutase SodC
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 3.82
Kyte-Doolittle Hydrophobicity Value -0.088
Molecular Weight (kDa) 18124.1
Isoelectric Point (pI) 8.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Response to superoxide
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism Mus musculus
Notes sodC mutation in K56-2 is attenuated for virulence in RAW 264.7 macrophages
Reference 17325048

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 88 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002305 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2643
Search term: sodC

Human Homologs

Ensembl 97, assembly GRCh38.p12
superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179]
E-value: 1.4e-05
Percent Identity: 34.8

References

Characterization of SodC, a periplasmic superoxide dismutase from Burkholderia cenocepacia.
Keith KE, Valvano MA
Infect Immun 2007 May;75(5):2451-60
PubMed ID: 17325048