Burkholderia cenocepacia J2315, BCAL2078 (lpxB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL2078
NCBI Locus TagQU43_RS46950
Name
lpxB
Replicon chromosome 1
Genomic location 2285510 - 2286679 (- strand)

Cross-References

RefSeq WP_006483810.1
GI 206560440
Entrez 6934054
GI 206560440
INSDC CAR52378.1
NCBI Locus Tag QU43_RS46950
NCBI Old Locus Tag BCAL2078
RefSeq WP_006483810.1,GeneID
UniParc UPI00017B94B1
UniProtKB Acc B4ECL8
UniProtKB ID LPXB_BURCJ
UniRef100 UniRef100_B4ECL8
UniRef50 UniRef50_Q13XC9
UniRef90 UniRef90_B4ECL8

Product

Feature Type CDS
Coding Frame 1
Product Name
lipid-A-disaccharide synthase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 3.87
Kyte-Doolittle Hydrophobicity Value 0.064
Molecular Weight (kDa) 42344.8
Isoelectric Point (pI) 8.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 382 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001896 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL2078
Search term: lpxB

Human Homologs

References

Complete structural characterization of the lipid A fraction of a clinical strain of B. cepacia genomovar I lipopolysaccharide.
Silipo A, Molinaro A, Cescutti P, Bedini E, Rizzo R, Parrilli M, Lanzetta R
Glycobiology 2005 May;15(5):561-70
PubMed ID: 15610978