Burkholderia cenocepacia J2315, BCAL1879 (hfq)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia cenocepacia J2315
Locus Tag
BCAL1879
NCBI Locus TagQU43_RS45940
Name
hfq
Replicon chromosome 1
Genomic location 2074649 - 2074888 (- strand)

Cross-References

RefSeq WP_006399927.1
GI 206560242
Entrez 6933706
GI 206560242
INSDC CAR52179.1
NCBI Locus Tag QU43_RS45940
NCBI Old Locus Tag BCAL1879
RefSeq WP_006399927.1,GeneID
UniParc UPI000029AD5F
UniProtKB Acc B4EAW4
UniProtKB ID HFQ_BURCJ
UniRef100 UniRef100_Q1BGW9
UniRef50 UniRef50_Q0C0N8
UniRef90 UniRef90_A3MK69

Product

Feature Type CDS
Coding Frame 1
Product Name
Hfq
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.70
Kyte-Doolittle Hydrophobicity Value -0.084
Molecular Weight (kDa) 8849.1
Isoelectric Point (pI) 9.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3SB2 CHAPERONE 06/03/11 Crystal Structure of the RNA chaperone Hfq from Herbaspirillum seropedicae SMR1 HERBASPIRILLUM SEROPEDICAE 2.6301 X-RAY DIFFRACTION 95.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 282 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001644 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL1879
Search term: hfq
Search term: Hfq

References

The second RNA chaperone, Hfq2, is also required for survival under stress and full virulence of Burkholderia cenocepacia J2315.
Ramos CG, Sousa SA, Grilo AM, Feliciano JR, Leitão JH.
J Bacteriol. 2011 Apr;193(7):1515-26.
PubMed ID: 21278292
The hfq gene is required for stress resistance and full virulence of Burkholderia cepacia to the nematode Caenorhabditis elegans.
Sousa SA, Ramos CG, Moreira LM, Leitão JH.
Microbiology. 2010 Mar;156(Pt 3):896-908.
PubMed ID: 19942656
Experimental identification of small non-coding regulatory RNAs in the opportunistic human pathogen Burkholderia cenocepacia J2315.
Ramos CG, Grilo AM, da Costa PJ, Leitão JH.
Genomics. 2012 Nov 8. pii: S0888-7543(12)00208-X.
PubMed ID: 23142676