Burkholderia cenocepacia J2315, BCAL0339 (tssJ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia cenocepacia J2315
GCF_000009485.1|latest
Locus Tag
BCAL0339
NCBI Locus TagQU43_RS38230
Name
tssJ
Synonym: bcsN
Replicon chromosome 1
Genomic location 365246 - 365845 (- strand)
CommentPart of the T6SS gene cluster

Cross-References

RefSeq YP_002229505.1
GI 206558745
Entrez 6930884
GI 206558745
INSDC CAR50649.1
NCBI Locus Tag QU43_RS38230
NCBI Old Locus Tag BCAL0339
RefSeq YP_002229505.1
UniParc UPI00017B90FD
UniProtKB Acc B4E6R1
UniProtKB ID B4E6R1_BURCJ
UniRef100 UniRef100_A0A095G2E5
UniRef50 UniRef50_Q8XRU0
UniRef90 UniRef90_A4JB17

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssJ
Product Name Confidence: Class 2
Synonyms putative type VI secretion system protein TssJ
Evidence for Translation
Charge (pH 7) 3.10
Kyte-Doolittle Hydrophobicity Value 0.176
Molecular Weight (kDa) 20791.9
Isoelectric Point (pI) 8.64

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 52 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000364 (626 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BCAL0339
Search term: tssJ

Human Homologs

References

A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.
Aubert DF, Flannagan RS, Valvano MA
Infect Immun 2008 May;76(5):1979-91
PubMed ID: 18316384
Towards a structural comprehension of bacterial type VI secretion systems: characterization of the TssJ-TssM complex of an Escherichia coli pathovar.
Felisberto-Rodrigues C, Durand E, Aschtgen MS, Blangy S, Ortiz-Lombardia M, Douzi B, Cambillau C, Cascales E
PLoS Pathog 2011 Nov;7(11):e1002386
PubMed ID: 22102820
Quantification of type VI secretion system activity in macrophages infected with Burkholderia cenocepacia.
Aubert DF, Hu S, Valvano MA
Microbiology 2015 Nov;161(11):2161-73
PubMed ID: 26364149