Burkholderia pseudomallei 1710b, BURPS1710b_A0568 (bipD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 1710b
GCF_000012785.1|latest
Locus Tag
BURPS1710b_A0568
NCBI Locus TagBURPS1710B_RS21320
Name
bipD
Synonym: ipaD
Replicon chromosome II
Genomic location 762562 - 763392 (- strand)

Cross-References

RefSeq YP_335727.1
GI 76817926
Entrez 3694243
GI 76817926
INSDC ABA51873.1
NCBI Locus Tag BURPS1710B_RS21320
NCBI Old Locus Tag BURPS1710b_A0568
RefSeq YP_335727.1
UniParc UPI000043BD1B
UniProtKB Acc Q3JL26
UniProtKB ID BIPD_BURP1
UniRef100 UniRef100_A3MCH1
UniRef50 UniRef50_Q2T708
UniRef90 UniRef90_A3MCH1

Product

Feature Type CDS
Coding Frame 1
Product Name
type III effector protein IpaD/SipD/SspD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -7.27
Kyte-Doolittle Hydrophobicity Value -0.397
Molecular Weight (kDa) 30324.9
Isoelectric Point (pI) 4.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Host Associated
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2J9T TOXIN 11/16/06 BipD of Burkholderia Pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.7 X-RAY DIFFRACTION 100.0
3NFT TRANSPORT PROTEIN 06/10/10 Near-atomic resolution analysis of BipD- A component of the type-III secretion system of Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 1.51 X-RAY DIFFRACTION 100.0
2IXR TOXIN 07/10/06 BipD of Burkholderia Pseudomallei BURKHOLDERIA PSEUDOMALLEI 2.6 X-RAY DIFFRACTION 100.0
2IZP TOXIN 07/25/06 BipD - an invasion protein associated with the type-III secretion system of Burkholderia pseudomallei. BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019830 (320 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS1710b_A0568
Search term: bipD

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.
Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ
Mol Microbiol 2007 Mar;63(6):1719-30
PubMed ID: 17367391