Burkholderia pseudomallei 1710b, BURPS1710b_A0562 (bopA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 1710b
GCF_000012785.1|latest
Locus Tag
BURPS1710b_A0562
NCBI Locus TagBURPS1710B_RS21290
Name
bopA
Replicon chromosome II
Genomic location 755544 - 757082 (- strand)

Cross-References

RefSeq WP_004528810.1
GI 76817646
Entrez 3694081
GI 76817646
INSDC ABA51593.1
NCBI Locus Tag BURPS1710B_RS21290
NCBI Old Locus Tag BURPS1710b_A0562
RefSeq WP_004528810.1
UniParc UPI000043BD16
UniProtKB Acc Q3JL32
UniProtKB ID BOPA_BURP1
UniRef100 UniRef100_Q3JL32
UniRef50 UniRef50_A3MCH8
UniRef90 UniRef90_A3MCH8

Product

Feature Type CDS
Coding Frame 1
Product Name
BopA protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 23.44
Kyte-Doolittle Hydrophobicity Value -0.525
Molecular Weight (kDa) 56831.6
Isoelectric Point (pI) 10.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database Victors : 1971
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Mus musculus
Notes BopA mutant was attenuated in mice
Reference 15621426
Source 2
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019823 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS1710b_A0562
Search term: bopA
Search term: BopA protein

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592