Burkholderia pseudomallei 1710b, BURPS1710b_A0561 (bicP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Burkholderia pseudomallei 1710b
GCF_000012785.1|latest
Locus Tag
BURPS1710b_A0561
NCBI Locus TagBURPS1710B_RS21285
Name
bicP
Synonym: sicP
Replicon chromosome II
Genomic location 754948 - 755403 (- strand)

Cross-References

RefSeq WP_004187648.1
GI 76819160
Entrez 3692059
GI 76819160
INSDC ABA53107.1
NCBI Locus Tag BURPS1710B_RS21285
NCBI Old Locus Tag BURPS1710b_A0561
RefSeq WP_004187648.1
UniParc UPI000043BD15
UniProtKB Acc Q3JL33
UniProtKB ID Q3JL33_BURP1
UniRef100 UniRef100_A0A095QSH1
UniRef50 UniRef50_Q2T702
UniRef90 UniRef90_Q2T702

Product

Feature Type CDS
Coding Frame 1
Product Name
Chaperone protein BicP
Product Name Confidence: Class 2
Synonyms putative chaperone
Evidence for Translation
Charge (pH 7) -13.10
Kyte-Doolittle Hydrophobicity Value 0.009
Molecular Weight (kDa) 16308.1
Isoelectric Point (pI) 4.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019822 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BURPS1710b_A0561
Search term: bicP

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system.
Button JE, Galán JE
Mol Microbiol 2011 Sep;81(6):1474-83
PubMed ID: 21801239