Burkholderia mallei ATCC 23344, BMAA1532 (bicA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia mallei ATCC 23344
GCF_000011705.1|latest |
| Locus Tag |
BMAA1532
|
| Name |
bicA
|
| Replicon | chromosome 2 |
| Genomic location | 1661830 - 1662300 (- strand) |
| Comment | This gene is part of the Burkholderia mallei type III secretion system T3SS-3 gene locus. |
Cross-References
| RefSeq | YP_106122.1 |
| GI | 53716466 |
| NCBI Locus Tag | BMAA1532 |
| RefSeq | YP_106122.1,GeneID |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
type III secretion chaperone protein BicA (T3SS-3)
|
| Synonyms |
type III secretion chaperone BicA |
| Evidence for Translation | |
| Charge (pH 7) | -3.93 |
| Kyte-Doolittle Hydrophobicity Value | -0.145 |
| Molecular Weight (kDa) | 17439.6 |
| Isoelectric Point (pI) | 5.57 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Virulence Evidence
| Source 1 | |
| Database | VFDB : VF0428 |
| Category | T3SS-3 |
| Evidence |
ECO:0000250
sequence similarity evidence used in manual assertion
|
| Host Organism | |
| Notes | |
| Annotation transferred from | Burkholderia pseudomallei K96243 |
| Reference | 17984080 |
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG019836 (323 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BMAA1532
Search term: bicA
Search term: type III secretion chaperone protein BicA (T3SS-3)
|
Human Homologs
References
|
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
|
|
Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei.
Sun GW, Chen Y, Liu Y, Tan GY, Ong C, Tan P, Gan YH
Mol Microbiol 2010 May;76(3):677-89
PubMed ID: 20345664
|
|
Characterization and analysis of the Burkholderia pseudomallei BsaN virulence regulon.
Chen Y, Schröder I, French CT, Jaroszewicz A, Yee XJ, Teh BE, Toesca IJ, Miller JF, Gan YH
BMC Microbiol 2014 Aug 1;14:206
PubMed ID: 25085508
|
|
Functional relatedness in the Inv/Mxi-Spa type III secretion system family.
Klein JA, Dave BM, Raphenya AR, McArthur AG, Knodler LA
Mol Microbiol 2017 Mar;103(6):973-991
PubMed ID: 27997726
|