Burkholderia mallei NCTC 10247, BMA10247_A0753 (bipB)

Gene Feature Overview

Strain	Burkholderia mallei NCTC 10247 GCF_000015625.1|latest
Locus Tag	BMA10247_A0753
NCBI Locus Tag	BMA10247_RS03090
Name	bipB Synonym: ipaB
Replicon	chromosome II
Genomic location	696312 - 698174 (+ strand)

Cross-References

RefSeq	WP_004533397.1
GI	126447280
Entrez	4889435
GI	126447280
INSDC	ABO03246.1
NCBI Locus Tag	BMA10247_RS03090
NCBI Old Locus Tag	BMA10247_A0753
RefSeq	WP_004533397.1
UniParc	UPI000043BD1E
UniProtKB Acc	A3MCG8
UniProtKB ID	BIPB_BURM7
UniRef100	UniRef100_A3MCG8
UniRef50	UniRef50_Q2T711
UniRef90	UniRef90_Q2T711

Product

Feature Type	CDS
Coding Frame	1
Product Name	BipB protein Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	-2.13
Kyte-Doolittle Hydrophobicity Value	-0.087
Molecular Weight (kDa)	64679.1
Isoelectric Point (pI)	6.23

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 3 20472543 Host Associated Note: This is based on PSORTb V3.0 secondary localization prediction Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	VFDB : VF0428
Category	T3SS-3
Evidence	ECO:0000250 sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from	Burkholderia pseudomallei K96243
Reference	17984080

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 15 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG019834 (323 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BMA10247_A0753 Search term: bipB Search term: BipB protein

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei. Sun GW, Gan YH Trends Microbiol 2010 Dec;18(12):561-8 PubMed ID: 20951592

The type III secretion system needle tip complex mediates host cell sensing and translocon insertion. Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ Mol Microbiol 2007 Mar;63(6):1719-30 PubMed ID: 17367391