Burkholderia mallei NCTC 10229, BMA10229_2076 (bipD)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Burkholderia mallei NCTC 10229
GCF_000015605.1|latest |
| Locus Tag |
BMA10229_2076
|
| NCBI Locus Tag | BMA10229_RS09000 |
| Name |
bipD
Synonym: ipaD Synonym: bprD |
| Replicon | chromosome II |
| Genomic location | 2127753 - 2128685 (+ strand) |
Cross-References
| RefSeq | WP_004188590.1 |
| GI | 124381675 |
| Entrez | 4788739 |
| GI | 124381675 |
| INSDC | ABN00020.2 |
| NCBI Locus Tag | BMA10229_RS09000 |
| NCBI Old Locus Tag | BMA10229_2076 |
| RefSeq | WP_004188590.1 |
| UniParc | UPI000043BD1B |
| UniProtKB Acc | A2S1Q1 |
| UniProtKB Acc | A2S1Q3 |
| UniProtKB ID | BIPD_BURM9 |
| UniProtKB ID | BIPD_BURM9 |
| UniRef100 | UniRef100_A3MCH1 |
| UniRef50 | UniRef50_Q2T708 |
| UniRef90 | UniRef90_A3MCH1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
BprD protein
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -7.03 |
| Kyte-Doolittle Hydrophobicity Value | -0.362 |
| Molecular Weight (kDa) | 33975.1 |
| Isoelectric Point (pI) | 4.96 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
| Look for predicted 3D structure in AlphaFold DB: Search |
| Look for predicted 3D structure in AlphaFold DB: Search |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2J9T | TOXIN | 11/16/06 | BipD of Burkholderia Pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.7 | X-RAY DIFFRACTION | 99.7 |
| 3NFT | TRANSPORT PROTEIN | 06/10/10 | Near-atomic resolution analysis of BipD- A component of the type-III secretion system of Burkholderia pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 1.51 | X-RAY DIFFRACTION | 99.7 |
| 2IXR | TOXIN | 07/10/06 | BipD of Burkholderia Pseudomallei | BURKHOLDERIA PSEUDOMALLEI | 2.6 | X-RAY DIFFRACTION | 99.7 |
| 2IZP | TOXIN | 07/25/06 | BipD - an invasion protein associated with the type-III secretion system of Burkholderia pseudomallei. | BURKHOLDERIA PSEUDOMALLEI | 2.1 | X-RAY DIFFRACTION | 99.7 |
Virulence Evidence
| Source 1 | |
| Database | VFDB : VF0428 |
| Category | T3SS-3 |
| Evidence |
ECO:0000250
sequence similarity evidence used in manual assertion
|
| Host Organism | |
| Notes | |
| Annotation transferred from | Burkholderia pseudomallei K96243 |
| Reference | 17984080 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 10 genera
|
Orthologs/Comparative Genomics
| Burkholderia Ortholog Group |
BG019830 (320 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: BMA10229_2076
Search term: bipD
Search term: BprD protein
|
Human Homologs
References
|
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
|
|
The type III secretion system needle tip complex mediates host cell sensing and translocon insertion.
Veenendaal AK, Hodgkinson JL, Schwarzer L, Stabat D, Zenk SF, Blocker AJ
Mol Microbiol 2007 Mar;63(6):1719-30
PubMed ID: 17367391
|