Burkholderia cenocepacia MC0-3, Bcenmc03_4201

Gene Feature Overview

Strain	Burkholderia cenocepacia MC0-3 GCF_000019505.1|latest
Locus Tag	Bcenmc03_4201
NCBI Locus Tag	BCENMC03_RS21180
Name
Replicon	chromosome 2
Genomic location	1137733 - 1138053 (- strand)

Cross-References

RefSeq	YP_001777842.1
GI	170736582
Entrez	6127034
GI	170736582
INSDC	ACA93352.1
NCBI Locus Tag	BCENMC03_RS21180
NCBI Old Locus Tag	Bcenmc03_4201
RefSeq	YP_001777842.1
UniParc	UPI000170D5AC
UniProtKB Acc	B1K7J9
UniProtKB ID	B1K7J9_BURCC
UniRef100	UniRef100_B1K7J9
UniRef50	UniRef50_Q13HT6
UniRef90	UniRef90_Q1BKX5

Product

Feature Type	CDS
Coding Frame	1
Product Name	type IV secretory pathway VirB3 family protein
Synonyms
Evidence for Translation
Charge (pH 7)	11.43
Kyte-Doolittle Hydrophobicity Value	0.372
Molecular Weight (kDa)	11883.3
Isoelectric Point (pI)	12.37

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 26 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG006326 (56 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: Bcenmc03_4201 Search term: type IV secretory pathway VirB3 family protein

Human Homologs

References

Involvement of a plasmid-encoded type IV secretion system in the plant tissue watersoaking phenotype of Burkholderia cenocepacia. Engledow AS, Medrano EG, Mahenthiralingam E, LiPuma JJ, Gonzalez CF J Bacteriol 2004 Sep;186(18):6015-24 PubMed ID: 15342570

Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2. Zhang R, LiPuma JJ, Gonzalez CF Microbiology 2009 Dec;155(Pt 12):4005-4013 PubMed ID: 19744991

A type IV secretion system contributes to intracellular survival and replication of Burkholderia cenocepacia. Sajjan SU, Carmody LA, Gonzalez CF, LiPuma JJ Infect Immun 2008 Dec;76(12):5447-55 PubMed ID: 18824538