Burkholderia thailandensis E264 ATCC 700388, BTH_I1472 (rmlD)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_I1472
NCBI Locus Tag	BTH_RS19710
Name	rmlD Synonym: rfbD
Replicon	chromosome I
Genomic location	1667202 - 1668098 (+ strand)
Transposon Mutants	2 transposon mutants in E264 ATCC 700388
Comment	Belongs to the Type II O-antigenic polysaccharide biosynthesis gene cluster

Cross-References

RefSeq	YP_442018.1
GI	83719857
Entrez	3847614
GI	83719857
INSDC	AIP24601.1
NCBI Locus Tag	BTH_RS19710
NCBI Old Locus Tag	BTH_I1472
RefSeq	WP_009889586.1
UniParc	UPI00006680BE
UniProtKB Acc	A0A096YJ00
UniProtKB ID	A0A096YJ00_BURTA
UniRef100	UniRef100_Q2SYI1
UniRef50	UniRef50_Q2SYI1
UniRef90	UniRef90_Q2SYI1

Product

Feature Type	CDS
Coding Frame	1
Product Name	dTDP-6-deoxy-l-lyxo-4-hexulose reductase RmlD Product Name Confidence: Class 1
Synonyms	dTDP-4-dehydrorhamnose reductase
Evidence for Translation
Charge (pH 7)	-0.10
Kyte-Doolittle Hydrophobicity Value	0.065
Molecular Weight (kDa)	31630.7
Isoelectric Point (pI)	6.95

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 493 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000733 (642 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_I1472 Search term: rmlD Search term: dTDP-6-deoxy-l-lyxo-4-hexulose reductase RmlD

Human Homologs

References

A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis. Yoo HG, Kwon SY, Karki S, Kwon HJ Bioorg Med Chem Lett 2011 Jul 1;21(13):3914-7 PubMed ID: 21640586