Burkholderia thailandensis E264 ATCC 700388, BTH_I1403 (scmR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_I1403
NCBI Locus TagBTH_RS19345
Name
scmR
Replicon chromosome I
Genomic location 1579170 - 1580150 (- strand)
Transposon Mutants 3 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_441949.1
GI 83719799
Entrez 3848481
GI 83719799
INSDC AIP25050.1
NCBI Locus Tag BTH_RS19345
NCBI Old Locus Tag BTH_I1403
RefSeq WP_009889425.1
UniParc UPI000066808A
UniProtKB Acc Q2SYQ0
UniProtKB ID Q2SYQ0_BURTA
UniRef100 UniRef100_Q2SYQ0
UniRef50 UniRef50_A9AFM0
UniRef90 UniRef90_A3NYM3

Product

Feature Type CDS
Coding Frame 1
Product Name
secondary metabolite regulator, ScmR
Product Name Confidence: Class 1
Synonyms LysR family transcriptional regulator
Evidence for Translation
Charge (pH 7) 3.00
Kyte-Doolittle Hydrophobicity Value -0.115
Molecular Weight (kDa) 35888.6
Isoelectric Point (pI) 7.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 474 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000688 (636 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_I1403
Search term: scmR

Human Homologs

References

Discovery of <i>scmR</i> as a global regulator of secondary metabolism and virulence in <i>Burkholderia thailandensis</i> E264.
Mao D, Bushin LB, Moon K, Wu Y, Seyedsayamdost MR
Proc Natl Acad Sci U S A 2017 Apr 4;114(14):E2920-E2928
PubMed ID: 28320949