Burkholderia thailandensis E264 ATCC 700388, BTH_II2139 (hmuR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2139
NCBI Locus TagBTH_RS10945
Name
hmuR
Replicon chromosome II
Genomic location 2626527 - 2628827 (+ strand)
Transposon Mutants 4 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_440327.1
GI 83717803
Entrez 3844711
GI 83717803
NCBI Locus Tag BTH_RS10945
NCBI Old Locus Tag BTH_II2139
RefSeq YP_440327.1
UniProtKB Acc Q2T3C2
UniProtKB ID Q2T3C2_BURTA

Product

Feature Type CDS
Coding Frame 1
Product Name
TonB-dependent outer membrane heme receptor HmuR
Product Name Confidence: Class 1
Synonyms TonB-dependent heme/hemoglobin receptor family protein
Evidence for Translation
Charge (pH 7) 12.09
Kyte-Doolittle Hydrophobicity Value -0.366
Molecular Weight (kDa) 82576.2
Isoelectric Point (pI) 9.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 329 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004242 (596 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2139
Search term: hmuR

Human Homologs

References

The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition.
Si M, Wang Y, Zhang B, Zhao C, Kang Y, Bai H, Wei D, Zhu L, Zhang L, Dong TG, Shen X
Cell Rep 2017 Jul 25;20(4):949-959
PubMed ID: 28746878