Burkholderia thailandensis E264 ATCC 700388, BTH_II2095 (malI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2095
Name
malI
Replicon chromosome II
Genomic location 2573204 - 2574466 (+ strand)
Transposon Mutants 4 transposon mutants in E264 ATCC 700388
CommentIncorrect translation start site called at 2571743 during initial annotation. The site was changed to 2573204 based on alignment with B. pseudomallei K96243 BPSS0303.
CommentBelongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq YP_440283.1
GI 83716834
Entrez 3845242
GI 83716834
INSDC ABC34723.1
NCBI Locus Tag BTH_II2095
RefSeq YP_440283.1
UniParc UPI0000667565
UniProtKB Acc Q2T3G6
UniProtKB ID Q2T3G6_BURTA
UniRef100 UniRef100_Q2T3G6
UniRef50 UniRef50_Q2T3G6
UniRef90 UniRef90_Q2T3G6

Product

Feature Type CDS
Coding Frame 1
Product Name
MalI
Synonyms diaminopimelate decarboxylase
Evidence for Translation
Charge (pH 7) -2.17
Kyte-Doolittle Hydrophobicity Value -0.053
Molecular Weight (kDa) 45655.5
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 587 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019787 (367 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2095
Search term: malI
Search term: MalI

Human Homologs

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Biggins JB, Ternei MA, Brady SF
J Am Chem Soc 2012 Aug 15;134(32):13192-5
PubMed ID: 22765305