Burkholderia thailandensis E264 ATCC 700388, BTH_II2092 (malE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2092
NCBI Locus TagBTH_RS10700
Name
malE
Replicon chromosome II
Genomic location 2557164 - 2558576 (+ strand)
CommentBelongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq YP_440280.1
GI 83717226
Entrez 3846305
GI 83717226
INSDC AIP25746.1
NCBI Locus Tag BTH_RS10700
NCBI Old Locus Tag BTH_II2092
RefSeq WP_009894049.1
UniParc UPI00006676E2
UniProtKB Acc Q2T3G9
UniProtKB ID Q2T3G9_BURTA
UniRef100 UniRef100_Q2T3G9
UniRef50 UniRef50_Q8ZPC9
UniRef90 UniRef90_Q2T3G9

Product

Feature Type CDS
Coding Frame 1
Product Name
MalE
Synonyms gamma-aminobutyraldehyde dehydrogenase
Evidence for Translation
Charge (pH 7) -2.02
Kyte-Doolittle Hydrophobicity Value 0.052
Molecular Weight (kDa) 49423.6
Isoelectric Point (pI) 6.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG016377 (377 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2092
Search term: malE
Search term: MalE

Human Homologs

Ensembl 97, assembly GRCh38.p12
aldehyde dehydrogenase 1 family member A2 [Source:HGNC Symbol;Acc:HGNC:15472]
E-value: 1.8e-76
Percent Identity: 36.4
Ensembl 97, assembly GRCh38.p12
aldehyde dehydrogenase 1 family member A2 [Source:HGNC Symbol;Acc:HGNC:15472]
E-value: 1.8e-76
Percent Identity: 36.4
Ensembl 97, assembly GRCh38.p12
aldehyde dehydrogenase 1 family member A2 [Source:HGNC Symbol;Acc:HGNC:15472]
E-value: 1.8e-76
Percent Identity: 36.4

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Biggins JB, Ternei MA, Brady SF
J Am Chem Soc 2012 Aug 15;134(32):13192-5
PubMed ID: 22765305