Burkholderia thailandensis E264 ATCC 700388, BTH_II2091 (malD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II2091
NCBI Locus TagBTH_RS10695
Name
malD
Replicon chromosome II
Genomic location 2555749 - 2557170 (+ strand)
Transposon Mutants 3 transposon mutants in E264 ATCC 700388
CommentBelongs to the malleilactone biosynthetic gene cluster

Cross-References

RefSeq YP_440279.1
GI 83717738
Entrez 3845017
GI 83717738
INSDC AIP24116.1
NCBI Locus Tag BTH_RS10695
NCBI Old Locus Tag BTH_II2091
RefSeq WP_009894048.1
UniParc UPI00006678D2
UniProtKB Acc Q2T3H0
UniProtKB ID Q2T3H0_BURTA
UniRef100 UniRef100_Q2T3H0
UniRef50 UniRef50_G2E6F7
UniRef90 UniRef90_Q2T3H0

Product

Feature Type CDS
Coding Frame 1
Product Name
MalD
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -3.09
Kyte-Doolittle Hydrophobicity Value -0.036
Molecular Weight (kDa) 51449.1
Isoelectric Point (pI) 6.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 639 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020489 (330 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II2091
Search term: malD
Search term: MalD

Human Homologs

Ensembl 97, assembly GRCh38.p12
ornithine aminotransferase [Source:HGNC Symbol;Acc:HGNC:8091]
E-value: 3.8e-26
Percent Identity: 29.8
Ensembl 97, assembly GRCh38.p12
ornithine aminotransferase [Source:HGNC Symbol;Acc:HGNC:8091]
E-value: 3.8e-26
Percent Identity: 29.8

References

Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.
Gupta A, Bedre R, Thapa SS, Sabrin A, Wang G, Dassanayake M, Grove A
ACS Chem Biol 2017 Dec 15;12(12):3012-3021
PubMed ID: 29087175
Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Biggins JB, Ternei MA, Brady SF
J Am Chem Soc 2012 Aug 15;134(32):13192-5
PubMed ID: 22765305