Burkholderia thailandensis E264 ATCC 700388, BTH_II1934 (hmqB)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_II1934
NCBI Locus Tag	BTH_RS09895
Name	hmqB
Replicon	chromosome II
Genomic location	2353157 - 2354038 (- strand)
Transposon Mutants	2 transposon mutants in E264 ATCC 700388
Comment	Belongs to the HMAQ biosynthesis operon hmqABCDEFG

Cross-References

RefSeq	YP_440128.1
GI	83716903
Entrez	3846683
GI	83716903
INSDC	AIP28157.1
NCBI Locus Tag	BTH_RS09895
NCBI Old Locus Tag	BTH_II1934
RefSeq	WP_009907997.1
UniParc	UPI00006675AA
UniProtKB Acc	Q2T3X1
UniProtKB ID	Q2T3X1_BURTA
UniRef100	UniRef100_Q2T3X1
UniRef50	UniRef50_B1Z5C1
UniRef90	UniRef90_Q2T3X1

Product

Feature Type	CDS
Coding Frame	1
Product Name	HmqB Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7)	-0.41
Kyte-Doolittle Hydrophobicity Value	0.174
Molecular Weight (kDa)	30290.0
Isoelectric Point (pI)	6.88

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543 Unknown (This protein may have multiple localization sites) Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 29 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG017404 (462 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_II1934 Search term: hmqB Search term: HmqB

Human Homologs

References

Burkholderia pseudomallei, B. thailandensis, and B. ambifaria produce 4-hydroxy-2-alkylquinoline analogues with a methyl group at the 3 position that is required for quorum-sensing regulation. Vial L, Lépine F, Milot S, Groleau MC, Dekimpe V, Woods DE, Déziel E J Bacteriol 2008 Aug;190(15):5339-52 PubMed ID: 18539738

Interplay between 4-Hydroxy-3-Methyl-2-Alkylquinoline and <i>N</i>-Acyl-Homoserine Lactone Signaling in a <i>Burkholderia cepacia</i> Complex Clinical Strain. Chapalain A, Groleau MC, Le Guillouzer S, Miomandre A, Vial L, Milot S, Déziel E Front Microbiol 2017;8:1021 PubMed ID: 28676791