Burkholderia thailandensis E264 ATCC 700388, BTH_II1238 (btaP)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_II1238
NCBI Locus Tag	BTH_RS06340
Name	btaP
Replicon	chromosome II
Genomic location	1476609 - 1478201 (+ strand)
Transposon Mutants	1 transposon mutants in E264 ATCC 700388
Comment	Belongs to the bactobolin biosynthetic gene cluster

Cross-References

RefSeq	YP_439434.1
GI	83717186
Entrez	3844558
GI	83717186
NCBI Locus Tag	BTH_RS06340
NCBI Old Locus Tag	BTH_II1238
RefSeq	WP_009896838.1
UniProtKB Acc	Q2T5W5
UniProtKB ID	Q2T5W5_BURTA

Product

Feature Type	CDS
Coding Frame	1
Product Name	BtaP
Synonyms	polyketide synthase
Evidence for Translation
Charge (pH 7)	-7.11
Kyte-Doolittle Hydrophobicity Value	-0.131
Molecular Weight (kDa)	58937.6
Isoelectric Point (pI)	6.39

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 105 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG017841 (392 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_II1238 Search term: btaP Search term: BtaP

Human Homologs

References

Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP J Bacteriol 2009 Jun;191(12):3909-18 PubMed ID: 19376863

Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J Org Lett 2011 Jun 17;13(12):3048-51 PubMed ID: 21615115

Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J Org Lett 2010 Feb 19;12(4):716-9 PubMed ID: 20095633