Burkholderia thailandensis E264 ATCC 700388, BTH_II1233 (btaK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II1233
NCBI Locus TagBTH_RS06315
Name
btaK
Replicon chromosome II
Genomic location 1457826 - 1462166 (+ strand)
Transposon Mutants 4 transposon mutants in E264 ATCC 700388
CommentBelongs to the bactobolin biosynthetic gene cluster

Cross-References

RefSeq YP_439429.1
GI 83716416
Entrez 3845000
GI 83716416
INSDC ABC34305.1
NCBI Locus Tag BTH_RS06315
NCBI Old Locus Tag BTH_II1233
RefSeq YP_439429.1
UniParc UPI00006673D0
UniProtKB Acc Q2T5X0
UniProtKB ID Q2T5X0_BURTA
UniRef100 UniRef100_A0A096YUY6
UniRef50 UniRef50_Q3JMA4
UniRef90 UniRef90_A0A096ZE56

Product

Feature Type CDS
Coding Frame 1
Product Name
BtaK
Synonyms peptide synthetase
Evidence for Translation
Charge (pH 7) -20.14
Kyte-Doolittle Hydrophobicity Value 0.004
Molecular Weight (kDa) 156133.6
Isoelectric Point (pI) 5.97

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 552 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020805 (313 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II1233
Search term: btaK
Search term: BtaK

Human Homologs

Ensembl 97, assembly GRCh38.p12
aminoadipate-semialdehyde dehydrogenase [Source:HGNC Symbol;Acc:HGNC:23993]
E-value: 6.9e-26
Percent Identity: 26.0
Ensembl 97, assembly GRCh38.p12
aminoadipate-semialdehyde dehydrogenase [Source:HGNC Symbol;Acc:HGNC:23993]
E-value: 6.9e-26
Percent Identity: 26.0
Ensembl 97, assembly GRCh38.p12
aminoadipate-semialdehyde dehydrogenase [Source:HGNC Symbol;Acc:HGNC:23993]
E-value: 6.9e-26
Percent Identity: 26.0
Ensembl 97, assembly GRCh38.p12
aminoadipate-semialdehyde dehydrogenase [Source:HGNC Symbol;Acc:HGNC:23993]
E-value: 6.9e-26
Percent Identity: 26.0
Ensembl 97, assembly GRCh38.p12
aminoadipate-semialdehyde dehydrogenase [Source:HGNC Symbol;Acc:HGNC:23993]
E-value: 6.9e-26
Percent Identity: 26.0

References

Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis.
Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP
J Bacteriol 2009 Jun;191(12):3909-18
PubMed ID: 19376863
Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.
Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J
Org Lett 2011 Jun 17;13(12):3048-51
PubMed ID: 21615115
Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J
Org Lett 2010 Feb 19;12(4):716-9
PubMed ID: 20095633