Burkholderia thailandensis E264 ATCC 700388, BTH_II1231 (btaR2)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_II1231
NCBI Locus Tag	BTH_RS06305
Name	btaR2
Replicon	chromosome II
Genomic location	1454107 - 1454811 (- strand)
Transposon Mutants	3 transposon mutants in E264 ATCC 700388
Comment	Belongs to the bactobolin biosynthetic gene cluster

Cross-References

RefSeq	YP_439427.1
GI	83716885
Entrez	3845176
GI	83716885
NCBI Locus Tag	BTH_RS06305
NCBI Old Locus Tag	BTH_II1231
RefSeq	YP_439427.1
UniProtKB Acc	Q2T5X2
UniProtKB ID	Q2T5X2_BURTA

Product

Feature Type	CDS
Coding Frame	1
Product Name	BtaR2
Synonyms	ATP-dependent transcription regulator LuxR
Evidence for Translation
Charge (pH 7)	0.44
Kyte-Doolittle Hydrophobicity Value	-0.179
Molecular Weight (kDa)	25870.9
Isoelectric Point (pI)	7.18

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543 Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	VFDB : VF0433
Category	Quorum sensing system
Evidence	ECO:0000250 sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from	Burkholderia pseudomallei K96243
Reference	17984080

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 269 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG003718 (1367 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_II1231 Search term: btaR2 Search term: BtaR2

Human Homologs

References

Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP J Bacteriol 2009 Jun;191(12):3909-18 PubMed ID: 19376863

Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy J Org Lett 2011 Jun 17;13(12):3048-51 PubMed ID: 21615115

Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J Org Lett 2010 Feb 19;12(4):716-9 PubMed ID: 20095633