Burkholderia thailandensis E264; ATCC 700388, BTH_II0260 (hcp-6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264; ATCC 700388
Locus Tag
BTH_II0260
NCBI Locus TagBTH_RS01350
Name
hcp-6
Replicon chromosome II
Genomic location 319462 - 319953 (+ strand)
Transposon Mutants 1 transposon mutants in E264; ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-6 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_438462.1
GI 83717048
Entrez 3846478
GI 83717048
INSDC AIP29420.1
NCBI Locus Tag BTH_RS01350
NCBI Old Locus Tag BTH_II0260
RefSeq WP_009895021.1
UniParc UPI0000667634
UniProtKB Acc Q2T8N7
UniProtKB ID Q2T8N7_BURTA
UniRef100 UniRef100_Q2T8N7
UniRef50 UniRef50_C9Y5D8
UniRef90 UniRef90_Q2T8N7

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssD-6
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -1.59
Kyte-Doolittle Hydrophobicity Value -0.246
Molecular Weight (kDa) 17133.2
Isoelectric Point (pI) 5.73

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 68 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG016585 (483 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0260
Search term: hcp-6

References

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD.
PLoS Pathog. 2010 Aug 26;6(8)
PubMed ID: 20865170
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434