Burkholderia pseudomallei K96243, BPSS1536 (bsaX)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSS1536
Name	bsaX Synonym: sctS
Replicon	chromosome 2
Genomic location	2090110 - 2090364 (- strand)
Comment	This gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq	YP_111542.1
GI	53722557
Entrez	3096689
GI	53722557
INSDC	CAH39009.1
NCBI Locus Tag	BPSS1536
RefSeq	YP_111542.1,GeneID
UniParc	UPI000043BD22
UniProtKB Acc	Q63K30
UniProtKB ID	Q63K30_BURPS
UniRef100	UniRef100_A0A069BAC3
UniRef50	UniRef50_A1JQ91
UniRef90	UniRef90_A0A069BAC3

Product

Feature Type	CDS
Coding Frame	1
Product Name	type III secretion system inner membrane export apparatus protein BsaX (T3SS-3) Product Name Confidence: Class 2
Synonyms	surface presentation of antigens protein
Evidence for Translation
Charge (pH 7)	-0.08
Kyte-Doolittle Hydrophobicity Value	1.206
Molecular Weight (kDa)	8861.7
Isoelectric Point (pI)	6.37

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Membrane Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	VFDB : VF0428
Category	T3SS-3
Evidence	ECO:0000314 direct assay evidence used in manual assertion
Host Organism
Notes
Reference	17984080

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 140 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG019839 (327 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSS1536 Search term: bsaX Search term: type III secretion system inner membrane export apparatus protein BsaX (T3SS-3)

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei. Sun GW, Gan YH Trends Microbiol 2010 Dec;18(12):561-8 PubMed ID: 20951592

Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>. Vander Broek CW, Stevens JM Front Cell Infect Microbiol 2017;7:255 PubMed ID: 28664152